Metaglez Forte Tablets

Introduction to Metaglez Forte Tablets

Metaglez Forte Tablet is a combination of Glipizide and Metformin which belongs to the group of medicines called Antidiabetic agents. It is used in adults to treat type II diabetes mellitus when diet, exercise and treatment with single agents does not result in adequate sugar control. Metaglaze Forte Tablets are manufactured by Aristo Pharma.

Metaglez Forte is an oral medication designed to manage type 2 diabetes mellitus effectively. It is a combination of two potent antidiabetic agents: Glimepiride and Metformin. This dual therapy aims to provide better glycemic control than monotherapy, targeting different mechanisms involved in glucose regulation.

Glimepiride, a sulfonylurea, works by stimulating the pancreatic beta cells to release insulin. This action is crucial for patients with type 2 diabetes, who often have an impaired insulin secretion response. By enhancing the release of insulin, Glimepiride helps lower blood sugar levels post-meal and throughout the day.

Uses of Metaglez Forte

Metaglez Forte, a combination medication containing Glimepiride and Metformin, is primarily used for the treatment of type 2 diabetes mellitus. Here are the key uses of Metaglez Forte:

• Glycemic Control
• Improvement of Insulin Sensitivity
• Combination Therapy
• Reduction of Long-term Complications
• Simplification of Treatment Regimen
• Adjunct to Lifestyle Modifications
• Initial Therapy

How Does Metaglez Forte Works?

Metaglez Forte Tablet stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, it can also reduce the amount of glucose produced by the liver and reduces its absorption in the body.

Side Effects of Metaglez Forte

Common Side Effects

• Hypoglycemia (low blood sugar levels)
• Nausea, vomiting
• Diarrhea
• Stomach Pain
• Loss of Appetite
• Changes in taste, metallic taste

Serious Side Effects

• Allergic reactions
• Severe dizziness or fainting
• Rapid or irregular heartbeat
• Severe or persistent headache
• Signs of liver problems
• Signs of kidney problems
• Unusual bleeding or bruising

Dosage of Metaglez Forte

• Dosage Strength: The “Forte” in the drug name may indicate a higher strength of the medication, but without additional information, it’s challenging to provide specific dosing details.
• Frequency of Administration: Some medications are taken once daily, while others may require multiple doses throughout the day.
• Timing: The timing of doses (e.g., with or without food) can vary depending on the medication.
• Titration: Some medications may require a starting dose that is gradually increased over time.
• Individualization: Dosages are often personalized for each patient based on their specific needs and response to the medication.

How to Manage Side Effects?

• Communicate with your healthcare provider
• Follow the prescribed dosage
• Take with or after food
• Stay hydrated
• Avoid alcohol and certain foods
• Manage pain or discomfort
• Get sufficient rest
• Monitor your symptoms

Warnings & Precautions

1. Lactic Acidosis Risk:

• This is a rare but serious side effect. Get emergency help if you feel very tired, have muscle pain, fast breathing, or feel dizzy.

2. Avoid Alcohol:

• Drinking alcohol while on Metasens increases the risk of lactic acidosis.

3. Surgery or X-ray Tests:

• Tell your doctor if you are having surgery or any test with iodine dye. You may need to stop the medicine temporarily.

4. Heart Issues:

• If you have heart failure or recently had a heart attack, talk to your doctor before using this medicine.

5. Dehydration:

• Avoid dehydration (from vomiting, diarrhea, or sweating a lot). It can harm your kidneys and increase side effects.

6. Elderly Caution:

• People over 65 years may be at higher risk for kidney problems and lactic acidosis.

7. Pregnancy and Breastfeeding:

• Use only if clearly needed. Always consult your doctor before using during pregnancy or breastfeeding.

8. Vitamin B12 Levels:

• Long-term use can lower vitamin B12, which may cause weakness or numbness. Blood tests may be needed.

Storage

• Store at room temperature – Between 15°C to 30°C (59°F to 86°F).
• Keep in a dry place – Avoid humid areas like bathrooms.
• Protect from sunlight – Store away from direct heat and light.
• Do not refrigerate or freeze.
• Keep out of reach of children and pets.
• Store in original packaging – Do not transfer to other containers.
• Do not use after expiry date – Check the date on the box or strip.

Frequently Asked Questions

1. How long does it take for Metaglez Forte to start working?

The onset of action can vary, but significant improvements in blood glucose levels can typically be seen within a few weeks of starting treatment, provided that diet and exercise are also adhered to.

2. What should I do if I miss a dose of Metaglez Forte?

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

3. Can Metaglez Forte cause hypoglycemia?

Yes, Glimepiride, one of the components of Metaglez Forte, can cause hypoglycemia, especially if meals are skipped or if the medication is taken with other antidiabetic medications that lower blood sugar.

4. Can Metaglez Forte be used in elderly patients?

Yes, Metaglez Forte can be used in elderly patients with type 2 diabetes. However, dosage adjustments may be necessary based on individual health status and kidney function.