Canmab 440mg Injection

Introduction to Canmab 440 mg Injection

Canmab 440mg Injection contains Trastuzumab which belongs to the group of medicines called Anti-cancer drugs. It is used to treat breast cancer and stomach cancer. It can be used either alone or in combination with other anticancer drugs (such as paclitaxel, cisplatin, docetaxel, 5-fluorouracil, capecitabine) or hormonal drugs (such as tamoxifen, anastrozole) to achieve better results. This medicine is manufactured by Biocon Ltd.

Canmab 440mg Injection will be administered to you only by an oncologist or by a trained professional into your vein or beneath the skin. It is suitable for use in patients with high levels of human epidermal growth factor 2 (HER2) or hormone receptor positive metastatic breast cancer (cancer this is more sensitive for hormonal changes).

Before receiving Canmab 440mg Injection inform your doctor if you have any heart problems (such as heart attack, heart valve disease, or abnormal heartbeat). You must also inform your doctor if you have hypertension as a precaution.

Canmab 440mg Injection is not recommended for use in patients with breathing difficulties. It is also not suitable for use in pregnant or breastfeeding women. Both men and women receiving Canmab 440mg Injection must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with Canmab 440mg Injection

The most common side effects of receiving this medicine are increased infections, sore throat, mouth ulcers, skin rashes, nausea, stomach upset, lack of sleep, weight loss, tingling and numbness of hands and feet, muscle pain, joint pain, hair loss, shakiness and increased sweating. Consult your doctor if any of these side effect worsens.

Uses of Canmab 440 mg

• Breast cancer (early and advanced)
• Stomach cancer (advanced)

How Does Canmab 440mg Works?

Canmab 440mg Injection is a monoclonal antibody. It works by blocking the actions of certain cellular proteins (HER2) that triggers cancer cell formation. It also blocks various downstream cell signalling pathways that triggers cancer growth within the body. As a result, it reduces cancer formation and prevents its further growth within the body

Side Effects of Canmab 440

Common Side Effects

• Increased infections
• Low RBC, WBC and platelet counts in blood
• Nausea, vomiting, diarrhea, stomach pain, constipation, indigestion
• Mouth ulcers, sore throat
• Bladder infection
• Headache, dizziness, tiredness, weakness
• Liver inflammation, weight loss, lack of appetite
• Pain, numbness, tingling sensation of hands and feet
• Restlessness, problems in falling asleep, anxiety, depression
• Flushing (skin redness), skin rash or itching, acne
• Eye inflammation, dry eyes or watery eyes
• Shortness of breath, runny nose, nasal itching and repeated sneezing
• Increased sweating, night sweats
• Muscle pain, joint pain, back pain, neck pain
• Swelling of the hands or ankles
• Breast inflammation

Rare Side Effects

• Fever, chills, flu-like symptoms, nausea, vomiting, increased muscle tension and shaking, headache, dizziness, breathing difficulties, high or low blood pressure, heart rhythm disturbances swelling of the face and lips, rash and tiredness
• Signs of heart failure (such as breathlessness, cough, fluid retention (swelling) in the legs or arms, palpitations)
• Kidney problems (weakness, shortness of breath, fatigue and confusion), heart problems (fluttering of the heart), fits, vomiting or Diarrhoea and tingling in the mouth, hands or fee

Dosage of Canmab 440 mg

Canmab 440 mg Injection contains an active ingredient, Trastuzumab, which is used in the treatment of breast cancer and stomach cancer. This medicine is available in various strengths and substitutes & must be given on doctor’s prescription only. You should consult your doctor for dosage and time because age and severity of the disease differ from person to person and it can only be judged by your doctor.

Adults are advised to take Canmab 440 mg Injection at a fixed time with or without food as instructed by your Doctor. You must take this medicine regularly on time for better results.

Other Dosages of Canmab 440mg

• Canmab 150mg

How to Manage Side Effects?

• Communicate with your healthcare team
• Pre-medication
• Monitor for allergic reactions
• Manage infusion reactions
• Fatigue management
• Heart health monitoring
• Nausea and vomiting
• Diarrhea management
• Maintain hydration
• Oral care

Warning & Precautions 

• Allergy
• Liver/kidney disease
• You must undergo biopsy test during Trastuzumab treatment to check the effect of Trastuzumab
• It is recommended to test the over expression of human epidermal growth factor receptor (HER2) before the administration of this medicine is initiated
• Regular monitoring of blood cell components is recommended while this medicine is being administered
• You should not drive or operate machinery while taking this medicine as it may cause dizziness
• You must always consult your doctor immediately to get best possible treatment when you are suffering from any of the above mentioned conditions

Safety Advice

• Medical Supervision
• Allergy Testing
• Heart Health Evaluation
• Infusion Setting
• Infusion Monitoring
• Medical History
• Pregnancy and Breastfeeding
• Avoid Live Vaccines
• Regular Check-ups
• Heart Monitoring during Treatment

Frequently Asked Questions

1. Is Canmab 440mg Injection used as a monotherapy in treating breast cancer?

Ans. Canmab 440mg Injection is generally given along with the chemotherapy medication such as paclitaxel or docetaxel or platinum compounds. Sometimes, it is also given with hormonal agents for those patients with elevated hormonal status.

2. Does Canmab 440mg Injection cause heart problems?

Ans. Canmab 440mg Injection is generally given along with the chemotherapy medication such as paclitaxel or docetaxel or platinum compounds. Sometimes, it is also given with hormonal agents for those patients with elevated hormonal status.

3. Can I breastfeed while on treatment with Canmab 440mg Injection?

Ans. No, since tends to pass into breast milk, it is unsafe to breastfeed. Hence, It is advised not to breastfeed for a minimum of 7 months after the treatment with Canmab 440mg Injection.

4. Can Canmab 440mg Injection be consumed during pregnancy?

Ans. No, it is unsafe to consume Canmab 440mg Injection while you are pregnant or this medicine can cause harm to the baby by reducing the amount of amniotic fluid, the fluid surrounding the womb. It can also cause organ developmental issues such as poor lung development when consumed during pregnancy. If you are planning for pregnancy, it is advised to discuss the birth control methods as this medicine may impair your fertility.