Canmab 440 mg Injection

Introduction to CCanmab 440 Mg Injection

Canmab 440mg Injection contains Trastuzumab which belongs to the group of medicines called Anti-cancer drugs. It is used to treat breast cancer and stomach cancer. It can be used either alone or in combination with other anticancer drugs (such as paclitaxel, cisplatin, docetaxel, 5-fluorouracil, capecitabine) or hormonal drugs (such as tamoxifen, anastrozole) to achieve better results.

This medicine is manufactured by Biocon Ltd. Canmab 440mg Injection will be administered to you only by an oncologist or by a trained professional into your vein or beneath the skin. It is suitable for use in patients with high levels of human epidermal growth factor 2 (HER2) or hormone receptor positive metastatic breast cancer (cancer this is more sensitive for hormonal changes).

Before receiving Canmab 440mg Injection inform your doctor if you have any heart problems (such as heart attack, heart valve disease, or abnormal heartbeat). You must also inform your doctor if you have hypertension as a precaution.

Canmab 440mg Injection is not recommended for use in patients with breathing difficulties. It is also not suitable for use in pregnant or breastfeeding women. Both men and women receiving Canmab 440mg Injection must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with Canmab 440mg Injection

Uses of Canmab 440 Mg

• HER2-positive cancers
• Metastatic Breast Cancer
• Early-Stage Breast Cancer
• Metastatic Gastric Cancer

How Does Canmab 440 Mg Work?

Canmab 440mg Injection is a monoclonal antibody. It works by blocking the actions of certain cellular proteins (HER2) that triggers cancer cell formation. It also blocks various downstream cell signalling pathways that triggers cancer growth within the body. As a result, it reduces cancer formation and prevents its further growth within the body

Side Effects of Canmab

Common Side Effects

• Infusion Reactions
• Fatigue & Weakness
• Nausea & Vomiting
• Heart Problems
• Low Blood Cell Count

Serious Side Effects

• Heart Problems
• Severe Allergic Reactions
• Liver Damage
• Low White Blood Cell Count (Neutropenia)
• Blood Clots & Stroke
• Severe Diarrhea & Dehydration

Dosage of Canmab 440 Mg

Canmab 440 mg Injection contains an active ingredient, Trastuzumab, which is used in the treatment of breast cancer and stomach cancer. This medicine is available in various strengths and substitutes & must be given on doctor’s prescription only.

You should consult your doctor for dosage and time because age and severity of the disease differ from person to person and it can only be judged by your doctor. Adults are advised to take Canmab 440 mg Injection at a fixed time with or without food as instructed by your Doctor.

You must take this medicine regularly on time for better results.

Strengths and Variants

• Canmab 150mg

How to Manage Side Effects?

• Communicate with your healthcare team
• Pre-medication
• Monitor for allergic reactions
• Manage infusion reactions
• Fatigue management
• Heart health monitoring
• Nausea and vomiting
• Diarrhea management
• Maintain hydration

Warning & Precautions 

1. Lung Toxicity:

• Canmab can cause serious lung problems, including inflammation, fluid buildup, or difficulty breathing. Patients with pre-existing lung conditions should be cautious.

2. Pregnancy & Breastfeeding:

• Canmab can harm an unborn baby. Women should use effective contraception during treatment and for at least 7 months after stopping. Breastfeeding should also be avoided.

3. Liver & Kidney Function:

• Patients with liver or kidney disease should be monitored, as Canmab can affect organ function and increase the risk of side effects.

4. Low White Blood Cell Count (Neutropenia):

• Canmab may weaken the immune system by reducing white blood cells, increasing the risk of infections. Regular blood tests are required.

5. Severe Diarrhea:

• Canmab may cause persistent or bloody diarrhea, leading to dehydration. Patients should stay hydrated and inform their doctor if diarrhea is severe.

6. Neurological Side Effects:

• Rare cases of seizures, confusion, dizziness, or loss of consciousness have been reported. Patients should report any unusual neurological symptoms.

7. Combination with Chemotherapy:

• When used with certain chemotherapy drugs, the risk of side effects like heart problems and infections increases. The doctor should assess the benefits and risks before combining treatments.

8. Hypersensitivity Reactions:

• Patients with known allergies to trastuzumab or similar drugs should avoid Canmab, as it may cause severe hypersensitivity reactions.

Safety Advice

• Medical Supervision
• Heart Health Evaluation
• Infusion Setting
• Infusion Monitoring
• Medical History
• Avoid Live Vaccines
• Regular Check-ups
• Heart Monitoring during Treatment

Frequently Asked Questions