Advamab 100mg Injection

Introduction to Advamab 100 mg Injection

Advamab 100mg Injection is an anticancer medication. It is used in the treatment of cancer of colon and rectum, non-small cell lung cancer, kidney cancer, brain tumor, ovarian and cervical cancer. It helps to prevent the growth of new blood vessels that feed tumors and stops tumors from growing.

It is manufactured by Alkem Laboratories. Alkem Laboratories Limited is an Indian multinational pharmaceutical company headquartered in Mumbai, that manufactures and sells pharmaceutical generics, formulations and nutraceuticals in India and globally.

Advamab 100mg Injection is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin.

Uses of Advamab 100 mg

Approved Uses of Advamab 100 mg Injection:

• Colorectal cancer
• Non-small cell lung cancer
• Glioblastoma multiforme
• Kidney cancer
• Breast cancer
• Cervical cancer

How Does Advamab 100 Works?

Advamab 100mg Injection contains Bevacizumab, a monoclonal antibody that works by targeting and inhibiting vascular endothelial growth factor (VEGF). VEGF is a protein produced by cells that stimulates the formation of new blood vessels.

Tumors release high amounts of VEGF to grow their own blood supply, which helps them get nutrients and oxygen to grow and spread. By blocking VEGF, Advamab effectively prevents the formation of new blood vessels (a process called angiogenesis) in the tumor.

Without a proper blood supply, the tumor is starved of nutrients and oxygen, which slows down its growth and can even shrink it over time. This action also helps limit the spread of cancer to other parts of the body.

Side Effects of Advamab 100

Common Side Effects

• High blood pressure
• Fatigue or weakness
• Nosebleeds
• Headache
• Mouth sores
• Loss of appetite
• Nausea or vomiting

Serious Side Effects

• Gastrointestinal Perforation
• Impaired Wound Healing
• Severe Bleeding (Hemorrhage)
• Blood Clots (Thrombosis)
• Kidney Problems (Nephrotic Syndrome)
• Reversible Posterior Leukoencephalopathy Syndrome (RPLS)

Dosage of Advamab 100

The dosage of Advamab 100mg Injection (Bevacizumab) depends on the type of cancer being treated, body weight, and overall health, but it is usually given as an intravenous infusion every 2 to 3 weeks, typically at a dose of 5 to 15 mg/kg. It must be administered by a healthcare professional under strict medical supervision.

How to Manage Side Effects?

• Stay hydrated to help reduce fatigue, manage constipation, and support kidney function.
• Monitor blood pressure regularly and inform your doctor of any spikes or symptoms like headaches or dizziness.
• Eat small, nutritious meals to help manage nausea, appetite loss, and weight loss.
• Use mild, fragrance-free skincare products to soothe dry or irritated skin.
• Avoid cuts or injuries and use a soft toothbrush to prevent bleeding or bruising.
• Report any unusual symptoms like severe pain, swelling, or vision changes to your doctor immediately.
• Plan surgeries carefully and inform your doctor well in advance to avoid wound healing complications.

Warnings & Precautions

Here are the key Warnings & Precautions for Advamab 100mg Injection (Bevacizumab):

1. Pregnancy and Breastfeeding:

• Not safe during pregnancy or while breastfeeding—may harm the baby.

2. Surgical Risk:

• Increases the risk of poor wound healing—avoid use 28 days before and after surgery.

3. Bleeding Risks:

• May lead to serious bleeding—avoid if you have a bleeding disorder or recent surgery.

4. Infection Risk:

• May weaken immune defenses—stay alert to fever, sore throat, or other infection signs.

5. Neurological Concerns:

• Rare risk of brain condition (RPLS)—watch for headaches, seizures, or vision changes.

6. Age Limit:

• Not recommended for use in children under 18 unless specifically directed by a specialist.

7. Medication Interactions:

• Inform your doctor about all other medicines or supplements being used.

Frequently Asked Questions

1. Is Advamab 100mg Injection used as standalone treatment in cancers?

Ans. Advamab 100mg Injection is a recombinant monoclonal antibody that belongs to the immunotherapy class of cancer treatment. It can either be used as monotherapy or in combination with chemotherapy or immunotherapy medications to improve the overall survival rate.

2. Is it safe for women to use Advamab 100mg Injection?

Ans. While for women with reproductive potential subjected to Advamab 100mg Injection, it is advised to discuss with your doctor regarding the effective birth control methods during the treatment. Also, to be continued for a minimum of 6 months after the treatment course completion as this medicine may impair fertility.

3. Is it safe to undergo a surgery during the treatment with Advamab 100mg Injection?

Ans. Advamab 100mg Injection is associated with increased risk of bleeding complications and poor wound healing. Hence, it is suggested to avoid planning for surgery and maintain an interval of 28 days before or after surgery.

4. Do the side effects of Advamab 100mg Injection last for a chronic period?

Ans. All the side effects that are relatively caused by Advamab 100mg Injection occur until the drug concentration stays in the body. It is found that this medicine will be contained in our body for almost 4 months after the final dose.