Introduction to Ketorolac Tromethamine Injection
Ketorolac injection is used for the short-term relief of moderately severe pain in people who are at least 17 years of age. Ketorolac injection should not be used for longer than 5 days, for mild pain, or for pain from chronic (long-term) conditions. You will receive your first doses of ketorolac by intravenous (into a vein) or intramuscular (into a muscle) injection in a hospital or medical office. After that, your doctor may choose to continue your treatment with oral ketorolac. You must stop taking oral ketorolac and using ketorolac injection on the fifth day after you received your first dose of ketorolac injection. Talk to your doctor if you still have pain after 5 days or if your pain is not controlled with this medication. Ketorolac may cause serious side effects.
People who are treated with nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as ketorolac may have a higher risk of having a heart attack or a stroke than people who are not treated with these medications. These events may happen without warning and may cause death. This risk may be higher for people who are treated with NSAIDs for a long time. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke or ‘ministroke;’ and if you have or have ever had high blood pressure. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.
Receiving ketorolac injection increases the risk that you will experience severe or uncontrolled bleeding. Tell your doctor if you have or have ever had a bleeding or clotting problem. Your doctor will probably not give you ketorolac injection.
Uses of Ketorolac Tromethamine
Ketorolac injection comes as a solution (liquid) to inject intramuscularly (into a muscle) or intravenously (into a vein). It is usually given every 6 hours on a schedule or as needed for pain by a healthcare provider in a hospital or medical office.
Here are some common uses for Ketorolac Tromethamine injection:
- Postoperative Pain Management
- Trauma and Injury
- Acute Pain
- Painful Procedures
- Renal Colic
- Cancer Pain
- Painful Inflammatory Conditions
- Migraine and Cluster Headaches
- Dental Pain
- Pain in Palliative Care
- Pain relief
- Short-term management of sudden moderate to severe pain that occurs usually after any surgical procedure
- Musculoskeletal pain
Ketorolac is used for the short-term treatment of moderate to severe pain. It is usually used before or after medical procedures or after surgery. Reducing pain helps you recover more comfortably so that you can return to your normal daily activities. This medication is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body’s production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever. Ketorolac should not be used for mild or long-term painful conditions (such as arthritis).
Ketorolac tromethamine, commonly known as Ketorol, is a nonsteroidal anti-inflammatory drug (NSAID) that is used for its analgesic (pain-relieving) and anti-inflammatory properties. It is available in various forms, including oral tablets, nasal spray, and injectable solution. The injectable form is particularly useful for situations where rapid pain relief is needed or when a patient cannot take medication orally.
How Does Ketorolac Tromethamine Injection Works?
Ketorol Injection works by blocking the effects of a substance produced during injury which causes inflammation and pain (prostaglandin) and it also inhibits the pain signals between the brain and nerve endings.
Ketorolac tromethamine, commonly known as Ketorol, is a nonsteroidal anti-inflammatory drug (NSAID). It works by inhibiting enzymes in the body called cyclooxygenases (COX-1 and COX-2). These enzymes play a role in the production of prostaglandins, which are chemicals involved in inflammation, pain, and fever.
Here’s how Ketorolac works:
- Inhibition of COX Enzymes
- Reduction of Prostaglandin Production
- Decreased Pain and Inflammation
Side Effects of Ketorolac Injection
Ketorolac injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away.
Some side effects can be serious. If you experience any of these symptoms or those listed in the imported warning section, stop using ketorolac injection and call your doctor immediately.
Ketorolac tromethamine injection, like all medications, can cause side effects. It’s important to be aware of these potential effects, although not everyone will experience them. If you are prescribed Ketorolac, your healthcare provider believes that the benefits outweigh the potential risks. Common side effects of Ketorolac tromethamine injection may include:
- yellowing of the skin or eyes
- Central Nervous System Effects
- Gastrointestinal Effects:
- Hematologic Effects
- ringing in the ears
- pain at injection site
- small red or purple dots on the skin
- Renal Effects
- unusual bleeding or bruising
- Allergic Reactions
- Liver Effects
- Hypersensitivity Reactions
- Respiratory Effects
- Vision Changes
- Psychiatric Effects
- Cardiovascular Effects
Ketorolac injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
Common Side Effects
- headache
- dizziness
- drowsiness
- diarrhea
- constipation
- gas
- sweating
- nausea
- flu-like symptoms
- pale skin
- fast heartbeat
- Dry mouth
- Nausea or Vomiting
Serious Side Effects
- Other Serious Effects
- Severe Skin Reactions
- Neurological Effects
- sores in the mouth
- lack of energy
- loss of appetite
- pain in the upper right part of the stomach
- excessive tiredness
Dosage of Ketorolac Tromethamine Injection
This does not apply. This medication is not for regular use.
Toradol is available as a 10 mg tablet and a solution (30 mg per ml) for intravenous (IV) or intramuscular (IM) administration. Toradol solution is administered as a single 15- to 60-mg dose once every 6 hours not to exceed 60 or 120 mg a day. The recommended oral dose is one to two Toradol tablets initially followed by one tablet every 4-6 hours, not to exceed 40 mg daily. Toradol should not be used for more than 5 days.
Ketorol injection will be administered to you only by a doctor or a nurse in a hospital and so you are unlikely to receive an overdose. However, consult your doctor or nurse if you feel any unusual symptoms.
The dosage of Ketorolac tromethamine injection can vary depending on factors like the patient’s age, weight, medical condition, and the specific situation for which it’s being administered. It’s crucial to follow the dosing instructions provided by a healthcare professional. The information below is a general guideline, but individual dosing may differ.
- Pain Management
- Postoperative Pain
- Duration of Use
- Switching to Oral Form
- Monitoring
- Contraindications and Precautions
How To Manage Side Effects?
Managing the side effects of Ketorolac tromethamine injection involves a combination of preventive measures and appropriate responses to specific symptoms.
If you experience side effects from Ketorolac tromethamine injection, it’s important to seek medical attention promptly. Some side effects may require immediate attention, while others may be managed with specific measures. Here are general steps for managing common side effects:
Warning & Precautions
Before using Ketorolac tromethamine injection, it’s important to be aware of certain warnings and precautions. This information is provided to ensure the safe and effective use of the medication. Here are some important warnings and precautions for Ketorolac tromethamine injection:
- Gastrointestinal Risk
- Cardiovascular Risk
- Renal Risk
- Hepatic Risk
- Bleeding Risk
- Aseptic Meningitis Syndrome
- Fluid Retention and Edema
- Elderly Patients
- Pediatric Use
- Pregnancy and Breastfeeding
- Concomitant Use with Other NSAIDs or Antiplatelet Agents
Safety Advice
- Administered by Healthcare Professionals
- Medical History
- Avoid Alcohol and Smoking
- Monitor Kidney Function
- Avoid Concurrent Use of Other NSAIDs or Antiplatelet Agents:
- Stay Well-Hydrated
- Report Side Effects
- Follow Dosage Instructions
- Attend Follow-Up Appointments
- Discontinue if Allergic Reaction Occurs
Frequently Asked Questions
1. What is Ketorolac tromethamine injection used for?
Ans. Ketorolac tromethamine injection is a nonsteroidal anti-inflammatory drug (NSAID) used for short-term pain relief, typically for moderate to severe pain after surgery, traumatic injury, or certain medical procedures.
2. How is Ketorolac tromethamine injection administered?
Ans. It is usually administered as an intravenous (IV) or intramuscular (IM) injection by a healthcare professional in a clinical setting.
3.Can Ketorolac tromethamine injection be used for chronic pain?
Ans. No, Ketorolac is generally not recommended for long-term use. It is intended for short-term pain relief, up to a maximum of 5 days.
4. How long can I use Ketorolac Tromethamine injection?
Ans. Ketorolac is typically used for short-term pain relief, up to a maximum of 5 days. Prolonged use can lead to an increased risk of side effects.
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