Tenepla 20mg Teneligliptin Tablets

Introduction to Tenepla 20mg Tablet

Tenepla 20mg Teneligliptin Tablets belong to a class of medications known as dipeptidyl peptidase-4 (DPP-4) inhibitors. This medication is primarily prescribed for the management of type 2 diabetes mellitus, a condition characterized by high blood sugar levels due to the body’s inability to properly use insulin.

Teneligliptin works by inhibiting the enzyme DPP-4, which is responsible for the breakdown of incretin hormones. Incretin hormones play a crucial role in regulating blood sugar levels by stimulating the release of insulin from the pancreas and decreasing the production of glucose by the liver. By inhibiting DPP-4, teneligliptin prolongs the action of incretin hormones, thereby increasing insulin secretion and decreasing blood sugar levels.

One of the significant advantages of teneligliptin is its once-daily dosing regimen, which improves patient adherence to treatment. Additionally, unlike some other medications used to treat type 2 diabetes, teneligliptin has a low risk of causing hypoglycemia (dangerously low blood sugar levels), making it a preferred choice for many patients, particularly those at risk of hypoglycemic episodes.

Clinical studies have demonstrated the efficacy and safety of teneligliptin in lowering blood sugar levels both as monotherapy and in combination with other antidiabetic medications such as metformin, sulfonylureas, and insulin. Furthermore, teneligliptin has shown favorable effects on other metabolic parameters, including body weight and lipid profile.

In addition to its glucose-lowering effects, teneligliptin has also been associated with potential benefits on cardiovascular health. Some studies suggest that DPP-4 inhibitors, including teneligliptin, may have cardioprotective effects by reducing inflammation, improving endothelial function, and exerting anti-atherosclerotic properties. These findings underscore the potential role of teneligliptin in reducing the risk of cardiovascular complications in patients with type 2 diabetes.

Uses of Tenepla 20mg

Tenepla 20mg Teneligliptin Tablets are primarily used for the management of type 2 diabetes mellitus. Here are the key uses of Tenepla 20mg:

• Blood Sugar Control
• Monotherapy
• Combination Therapy
• Once-Daily Dosage
• Low Risk of Hypoglycemia

How Does Tenepla 20 Works?

Tenepla 20mg Teneligliptin Tablets work by targeting a key enzyme called dipeptidyl peptidase-4 (DPP-4), which plays a crucial role in glucose metabolism. Here’s how Tenepla 20mg works:

• Inhibition of DPP-4
• Prolongation of Incretin Hormone Action
• Stimulation of Insulin Secretion
• Inhibition of Glucagon Secretion
• Delay of Gastric Emptying

Side Effects of Tenepla 20mg

Common Side Effects

• Upper Respiratory Tract Infections
• Nasopharyngitis
• Headache
• Gastrointestinal Disturbances
• Dizziness
• Joint Pain
• Back Pain

Serious Side Effects

• Pancreatitis
• Hypersensitivity Reactions
• Hypoglycemia
• Joint Pain
• Bullous Pemphigoid
• Liver Dysfunction

Rare Side Effects

• Bullous Pemphigoid
• Severe Hypersensitivity Reactions
• Acute Pancreatitis
• Liver Dysfunction
• Interstitial Lung Disease

How To Manage Side Effects?

Managing side effects of Tenepla 20mg Teneligliptin Tablets involves several strategies to alleviate symptoms and ensure the safety and well-being of the patient. Here are some general guidelines for managing side effects:

• Communication with Healthcare Provider
• Medication Review
• Symptomatic Treatment
• Monitoring
• Dose Adjustment
• Addressing Underlying Conditions
• Patient Education
• Adherence to Treatment Plan

Warning & Precautions

Tenepla 20mg Teneligliptin Tablets come with several warnings and precautions that patients and healthcare providers should be aware of to ensure safe and effective use. Here are some important warnings and precautions associated with Tenepla 20mg:

1. Hypoglycemia:

• Tenepla 20mg may increase the risk of hypoglycemia (low blood sugar), especially when used in combination with other antidiabetic medications such as sulfonylureas or insulin. Patients should be educated about the signs and symptoms of hypoglycemia and how to manage it, including the use of glucose tablets or gel, fruit juice, or candy to raise blood sugar levels.

2. Pancreatitis:

• Rare cases of pancreatitis (inflammation of the pancreas) have been reported with the use of DPP-4 inhibitors like teneligliptin. Patients should be advised to seek medical attention if they experience persistent, severe abdominal pain, which may be a symptom of pancreatitis.

3. Hypersensitivity Reactions:

• Allergic reactions, including rash, itching, swelling of the face, lips, or tongue, and difficulty breathing, have been reported with teneligliptin use. Patients should be monitored for signs of hypersensitivity, and the medication should be discontinued if an allergic reaction occurs.

4. Bullous Pemphigoid:

• Rare cases of bullous pemphigoid, a skin disorder characterized by blistering lesions, have been reported with the use of DPP-4 inhibitors like teneligliptin. Patients should be advised to seek medical attention if they develop blistering skin lesions while taking Tenepla 20mg.

5. Renal Impairment:

• Tenepla 20mg should be used with caution in patients with renal impairment, as teneligliptin is primarily excreted through the kidneys. Dosage adjustments may be necessary based on the patient’s level of renal function.

6. Liver Dysfunction:

• Liver dysfunction, including abnormalities in liver function tests, has been reported with the use of teneligliptin. Patients with liver disease should be monitored closely while taking Tenepla 20mg, and the medication should be used with caution in this population.

7. Heart Failure:

• DPP-4 inhibitors like teneligliptin have been associated with an increased risk of heart failure, particularly in patients with a history of heart failure or other cardiovascular risk factors. Patients should be monitored for signs and symptoms of heart failure, such as shortness of breath, swelling of the ankles or feet, and fatigue.

8. Pregnancy and Lactation:

• The safety of teneligliptin during pregnancy and lactation has not been established. Tenepla 20mg should only be used in pregnant or breastfeeding women if the potential benefits outweigh the risks to the fetus or infant.

Safety Advice

• Use as Prescribed
• Regular Monitoring
• Hypoglycemia Awareness
• Pancreatitis Risk
• Allergic Reactions
• Liver Function Monitoring
• Heart Failure Risk
• Pregnancy and Breastfeeding
• Other Medications and Supplements
• Follow-up Appointments

Frequently Asked Questions

1. Are there any contraindications for Tenepla?

Ans. Tenepla is contraindicated in patients with a history of hypersensitivity to teneligliptin or any of the other ingredients in the formulation.

2. Is Tenepla safe for use during pregnancy and breastfeeding?

Ans. The safety of Tenepla during pregnancy and breastfeeding has not been established. It’s crucial to consult your doctor before taking this medication if you are pregnant or breastfeeding.

3. What should I do if I miss a dose of Tenepla?

Ans. If you miss a dose of Tenepla, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

4. How should Tenepla be stored?

Ans. Tenepla should be stored at room temperature, away from moisture and heat. Keep it out of reach of children and pets.